Fish, written by Melis Aker and directed by Tatiana Pandiani, is a darkly comic coming-of-age drama inspired by true events about a teenage girl whose search for her missing brother takes a disturbing turn. Set in London in 2016, the play follows 17-year-old Karya as she tests her Turkish mother’s increasingly plausible theory about her brother’s disappearance by launching an online experiment with her best friend, only to discover that some games carry sinister consequences.

On entering St. Ann’s Warehouse for Daniel Fish’s Kramer/Fauci, the entire expanse of the building is visible. The floor is matte black, and on the far wall a bank of lights beams intensely toward the audience, replicating a high school football stadium in Texas. Although the scenic design is credited to Jim Findlay, Joshua Higgason, and Amy Rubin, and the lighting to Scott Zielinski, the importance is the actors, who re-create a 1993 C-SPAN interview with writer (the novel Faggots; the play The Normal Heart) and ACT UP activist Larry Kramer (Thomas Jay Ryan) and Dr. Anthony Fauci (Will Brill), then known as the premier AIDS researcher in the country.

Anachronisms are a reliable source of fun and surprise in musicals, from the very casting and concept of Hamilton going back to “On any gent who wandered by, she’d pull the Theda Bara eye” (“Cleopatterer,” Leave It to Jane, 1917). But anachronisms have seldom had as strenuous a workout as the one they endure in Slam Frank, the musical at the Orpheum. The work of Joel Sinensky (book) and Andrew Fox (music and lyrics), it aims essentially to resurrect a mid-century classic, burden it with pop culture signposts from a variety of eras, reassess its relevance in these troubled times, and find it wanting. Which it does in an anything-for-a-laugh way, to the point where your sides may be sore from being poked in the ribs so relentlessly.

Warnings about the consequences of global warming come early and often in the Off-Broadway premiere of Nick Blaemire’s 2015 pop musical, Soon. But they are a false flag. This is no treatise on the fragility of the physical world. Instead, it is the study of a young woman’s psyche as she wends her way through what often feels like a traditional romantic comedy only to arrive at a surprising crisis point where she risks drowning in her own emotional meltdown.

The word belong becomes an obsession for stoker Yank (Jon Beavers) in Eugene O’Neill’s 1922 play The Hairy Ape. Yank has spent his life shoveling coal on a transatlantic liner, and he is the tallest and seemingly strongest of the men doing that work in Ciarán O’Reilly’s engrossing production at the Irish Rep. Yank sees himself as the solid foundation of the entire society, but when a socialite visits the stokehold, it launches him on a downward spiral. He becomes obsessed with the idea that she could look at him only as a “hairy ape.”